Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2080563..2081092 Replicon chromosome
Accession NC_022113
Organism Staphylococcus aureus subsp. aureus 55/2053

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag SAAG_RS10455 Protein ID WP_000621176.1
Coordinates 2080563..2080925 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag SAAG_RS10460 Protein ID WP_000948331.1
Coordinates 2080922..2081092 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAAG_RS10430 2077541..2078311 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
SAAG_RS10435 2078286..2078765 - 480 WP_001190825.1 anti-sigma B factor RsbW -
SAAG_RS10440 2078767..2079093 - 327 WP_001052491.1 anti-sigma factor antagonist -
SAAG_RS10445 2079212..2080213 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
SAAG_RS10455 2080563..2080925 - 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SAAG_RS10460 2080922..2081092 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
SAAG_RS10465 2081177..2082325 - 1149 WP_001281140.1 alanine racemase -
SAAG_RS10470 2082391..2082750 - 360 WP_000581197.1 holo-ACP synthase -
SAAG_RS10475 2082754..2083245 - 492 WP_001286801.1 PH domain-containing protein -
SAAG_RS10480 2083238..2084815 - 1578 WP_001294647.1 PH domain-containing protein -
SAAG_RS10485 2084808..2085287 - 480 WP_001287082.1 hypothetical protein -
SAAG_RS10490 2085496..2086056 - 561 WP_001092414.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T29930 WP_000621176.1 NC_022113:c2080925-2080563 [Staphylococcus aureus subsp. aureus 55/2053]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T29930 NC_022113:c2080925-2080563 [Staphylococcus aureus subsp. aureus 55/2053]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACATACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGTTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT29930 WP_000948331.1 NC_022113:c2081092-2080922 [Staphylococcus aureus subsp. aureus 55/2053]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT29930 NC_022113:c2081092-2080922 [Staphylococcus aureus subsp. aureus 55/2053]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References