Detailed information of TA system TA029838

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 2246348..2246913
• Replicon: chromosome
• Accession: NC_021847
• Organism: Vibrio parahaemolyticus O1:Kuk str. FDA R31

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A916ASF8
• Locus tag: HK86_RS10365
• Protein ID: WP_005445239.1
• Coordinates: 2246348..2246635 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3BLE1
• Locus tag: HK86_RS10370
• Protein ID: WP_000086647.1
• Coordinates: 2246632..2246913 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HK86_RS10340	2242329..2242838	+	510	WP_020840754.1	hypothetical protein	-
HK86_RS10345	2242974..2243795	-	822	WP_020840755.1	HNH endonuclease	-
HK86_RS24730	2243824..2243916	-	93	WP_079854941.1	DUF3265 domain-containing protein	-
HK86_RS24095	2244033..2244557	-	525	WP_020840756.1	hypothetical protein	-
HK86_RS10355	2244554..2245315	-	762	WP_123768137.1	hypothetical protein	-
HK86_RS24735	2245617..2245724	-	108	WP_162471491.1	DUF3265 domain-containing protein	-
HK86_RS26770	2245835..2246128	+	294	WP_162471482.1	hypothetical protein	-
HK86_RS24740	2246228..2246320	-	93	WP_079881687.1	DUF3265 domain-containing protein	-
HK86_RS10365	2246348..2246635	-	288	WP_005445239.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HK86_RS10370	2246632..2246913	-	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HK86_RS10375	2247159..2247449	-	291	WP_079751593.1	YkgJ family cysteine cluster protein	-
HK86_RS10380	2247884..2248066	-	183	WP_020840761.1	hypothetical protein	-
HK86_RS10385	2248213..2248524	-	312	WP_020840762.1	antibiotic biosynthesis monooxygenase	-
HK86_RS24745	2248561..2248653	-	93	WP_193773967.1	DUF3265 domain-containing protein	-
HK86_RS10390	2248668..2249141	-	474	WP_020840763.1	GrpB family protein	-
HK86_RS24750	2249170..2249259	-	90	WP_079752447.1	DUF3265 domain-containing protein	-
HK86_RS10395	2249288..2249740	-	453	WP_020840764.1	hypothetical protein	-
HK86_RS10400	2250033..2250359	+	327	WP_020840765.1	hypothetical protein	-
HK86_RS10405	2250346..2250732	+	387	WP_020840766.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2200026..2464903	264877
	-	inside	Integron	-	-	2233756..2250359	16603

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11031.70 Da
• Isoelectric Point: 5.1098

>T29838 WP_005445239.1 NC_021847:c2246635-2246348 [Vibrio parahaemolyticus O1:Kuk str. FDA_R31]
MKVVWSPLALQKLGDAAEFISLDNPPAAERWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Nucleotide

• Length: 288 bp

>T29838 NC_021847:c2246635-2246348 [Vibrio parahaemolyticus O1:Kuk str. FDA_R31]
ATGAAAGTAGTCTGGTCTCCATTAGCACTTCAGAAACTAGGTGATGCAGCGGAGTTTATTTCTTTGGATAACCCACCTGC
AGCAGAGAGGTGGGTAAACGAAGTTTTTGATAAAACTGAACTACTTGGAAGTATGCCTGAAATGGGGCGGTTTGTTCCTG
AAATGCCCCACACGAACTATCGCGAAATCATCTTTGGTCACTATCGTATTATCTACAGTTTAAGTCACGAAATCCGCGTA
CTAACAGTTCGTAATTGTCGTCAAATTTTATCGGAAGATGACGTGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10398.91 Da
• Isoelectric Point: 5.8650

>AT29838 WP_000086647.1 NC_021847:c2246913-2246632 [Vibrio parahaemolyticus O1:Kuk str. FDA_R31]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT29838 NC_021847:c2246913-2246632 [Vibrio parahaemolyticus O1:Kuk str. FDA_R31]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCTTTGTCTGAGTTTCGTGCCGGTGTAGCTTCATACATCAAACAAAT
CAATGAGACTCGTCGTCCATTGGTTATTACGCAACGTGGCAAAGGTGTTGCTGTTGTTCTCGATGTTGCTGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTGGAAGAAATGCGCACAGCAGAAGCTCAGTTAGCTTCTGGTCTCGGTGTTTCCAAT
GATGATGCGCGTGCTCAAGTACTTGGGCGCATTAAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A4P8G0X0