Detailed information of TA system TA029833

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-MazE
• Location: 33340..33917
• Replicon: plasmid unnamed
• Accession: NC_021828
• Organism: Listeria monocytogenes

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: H1G8D6
• Locus tag: HK87_RS15385
• Protein ID: WP_003728465.1
• Coordinates: 33576..33917 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: H1G8D5
• Locus tag: HK87_RS15380
• Protein ID: WP_003728464.1
• Coordinates: 33340..33582 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HK87_RS15335	28612..29328	-	717	WP_003731678.1	AP2 domain-containing protein	-
HK87_RS15340	29344..30066	-	723	WP_003728517.1	CRISPR-associated protein Cas5	-
HK87_RS15345	30070..30495	-	426	WP_003728518.1	hypothetical protein	-
HK87_RS15350	30496..30744	-	249	WP_003728519.1	hypothetical protein	-
HK87_RS15355	30866..31354	-	489	WP_003728520.1	hypothetical protein	-
HK87_RS15360	31513..31890	-	378	WP_003769263.1	DUF3850 domain-containing protein	-
HK87_RS15365	31909..32571	-	663	WP_003731676.1	DUF2786 domain-containing protein	-
HK87_RS15370	32571..32897	-	327	WP_003728462.1	hypothetical protein	-
HK87_RS15375	33028..33279	+	252	WP_003728463.1	hypothetical protein	-
HK87_RS15380	33340..33582	+	243	WP_003728464.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HK87_RS15385	33576..33917	+	342	WP_003728465.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HK87_RS15390	34110..36245	-	2136	WP_003728466.1	cadmium-translocating P-type ATPase	-
HK87_RS15395	36245..36604	-	360	WP_003728467.1	Cd(II)-sensing metalloregulatory transcriptional repressor CadC	-
HK87_RS15400	36884..37438	+	555	WP_003728468.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..57557	57557

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-125)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-57)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 14629.86 Da
• Isoelectric Point: 12.8531

>T29833 WP_003728465.1 NC_021828:33576-33917 [Listeria monocytogenes]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 342 bp

>T29833 NC_021828:33576-33917 [Listeria monocytogenes]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 10400.12 Da
• Isoelectric Point: 12.7030

>AT29833 WP_003728464.1 NC_021828:33340-33582 [Listeria monocytogenes]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
K

Nucleotide

• Length: 243 bp

>AT29833 NC_021828:33340-33582 [Listeria monocytogenes]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAA

Structures

Toxin

• AlphaFold DB: H1G8D6

Antitoxin

• AlphaFold DB: H1G8D5