Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 121607..122211 Replicon chromosome
Accession NZ_OX365700
Organism Nitrospira sp. DNF

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QWI75_RS00585 Protein ID WP_289266738.1
Coordinates 121915..122211 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QWI75_RS00580 Protein ID WP_289266737.1
Coordinates 121607..121918 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QWI75_RS00555 (DNFV4_00123) 118101..118601 + 501 WP_289266732.1 DoxX family protein -
QWI75_RS00560 (DNFV4_00124) 118657..119616 + 960 WP_289266733.1 hypothetical protein -
QWI75_RS00565 (DNFV4_00126) 120086..120379 + 294 WP_289266734.1 putative addiction module antidote protein -
QWI75_RS00570 (DNFV4_00127) 120527..120859 + 333 WP_289266735.1 hypothetical protein -
QWI75_RS00575 (DNFV4_00128) 120910..121449 + 540 WP_289266736.1 hypothetical protein -
QWI75_RS00580 (DNFV4_00129) 121607..121918 - 312 WP_289266737.1 NadS family protein Antitoxin
QWI75_RS00585 (DNFV4_00130) 121915..122211 - 297 WP_289266738.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QWI75_RS00590 122473..122577 + 105 WP_289266739.1 type II toxin-antitoxin system VapB family antitoxin -
QWI75_RS00595 (DNFV4_00132) 123474..123704 + 231 WP_289266740.1 4-oxalocrotonate tautomerase family protein -
QWI75_RS00600 (DNFV4_00133) 123856..124842 - 987 WP_289266741.1 hypothetical protein -
QWI75_RS00605 (DNFV4_00134) 125367..126002 - 636 WP_289266742.1 thiopurine S-methyltransferase -
QWI75_RS00610 (DNFV4_00135) 126141..126596 - 456 WP_289266743.1 YbhB/YbcL family Raf kinase inhibitor-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(35-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-77)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11202.97 Da        Isoelectric Point: 10.4878

>T296740 WP_289266738.1 NZ_OX365700:c122211-121915 [Nitrospira sp. DNF]
VFTAAVRRQLDDESYRALQLALLLRPTQGPIIQGGAGLRKLRWAAEGRGKRGGVRLIYYWEPASQTFYMLYLYAKNEQGD
LTADQLKVLAKLVRREFS

Download         Length: 297 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11437.40 Da        Isoelectric Point: 12.4067

>AT296740 WP_289266737.1 NZ_OX365700:c121918-121607 [Nitrospira sp. DNF]
MKDTAFQELLTSIRQAGRIRRGTLKPARVTTFRPADVKSIREKLKASQAEFALMIGVSIATLRNWEQGRRRPEGPALALL
RVAARNPRAVAEALHRPPRKGAA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References