Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2473197..2473381 Replicon chromosome
Accession NZ_OX344719
Organism Staphylococcus aureus strain ST20190863 isolate ST20190863

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag OOL12_RS12390 Protein ID WP_000482650.1
Coordinates 2473197..2473304 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2473321..2473381 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOL12_RS12365 2468559..2469032 + 474 WP_000456489.1 GyrI-like domain-containing protein -
OOL12_RS12370 2469155..2470366 - 1212 WP_001192076.1 multidrug effflux MFS transporter -
OOL12_RS12375 2470548..2471207 - 660 WP_000831298.1 membrane protein -
OOL12_RS12380 2471267..2472409 - 1143 WP_001176863.1 glycerate kinase -
OOL12_RS12385 2472677..2473063 + 387 WP_000779358.1 flippase GtxA -
OOL12_RS12390 2473197..2473304 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2473321..2473381 - 61 - - Antitoxin
OOL12_RS12395 2473932..2475695 + 1764 WP_001064838.1 ABC transporter ATP-binding protein -
OOL12_RS12400 2475720..2477453 + 1734 WP_000486494.1 ABC transporter ATP-binding protein -
OOL12_RS12405 2477684..2477851 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T296606 WP_000482650.1 NZ_OX344719:2473197-2473304 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT296606 NZ_OX344719:c2473381-2473321 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References