Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5003303..5004984 Replicon chromosome
Accession NZ_OW970444
Organism Klebsiella pneumoniae isolate 101

Toxin (Protein)


Gene name mosT Uniprot ID J2XCI1
Locus tag LQV08_RS24570 Protein ID WP_004146663.1
Coordinates 5003303..5004220 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag LQV08_RS24575 Protein ID WP_032418188.1
Coordinates 5004226..5004984 (-) Length 253 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV08_RS24550 (4998609) 4998609..5000129 + 1521 WP_032418186.1 sugar ABC transporter ATP-binding protein -
LQV08_RS24555 (5000126) 5000126..5001124 + 999 WP_002885172.1 ribose ABC transporter permease -
LQV08_RS24560 (5001155) 5001155..5002096 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
LQV08_RS24565 (5002171) 5002171..5003178 + 1008 WP_032418187.1 carbohydrate kinase family protein -
LQV08_RS24570 (5003303) 5003303..5004220 - 918 WP_004146663.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LQV08_RS24575 (5004226) 5004226..5004984 - 759 WP_032418188.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
LQV08_RS24580 (5005070) 5005070..5005798 - 729 WP_004210017.1 response regulator transcription factor -
LQV08_RS24585 (5006071) 5006071..5008218 + 2148 WP_077598926.1 formate dehydrogenase subunit alpha -
LQV08_RS24590 (5008215) 5008215..5008358 - 144 WP_022631365.1 hypothetical protein -
LQV08_RS24595 (5008564) 5008564..5009250 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34659.10 Da        Isoelectric Point: 5.4707

>T296347 WP_004146663.1 NZ_OW970444:c5004220-5003303 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp


Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28620.99 Da        Isoelectric Point: 10.0001

>AT296347 WP_032418188.1 NZ_OW970444:c5004984-5004226 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPETLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB J2XCI1


Antitoxin

Source ID Structure

References