Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3936461..3937058 Replicon chromosome
Accession NZ_OW970444
Organism Klebsiella pneumoniae isolate 101

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag LQV08_RS19295 Protein ID WP_004142563.1
Coordinates 3936741..3937058 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag LQV08_RS19290 Protein ID WP_004142561.1
Coordinates 3936461..3936748 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV08_RS19260 (3932542) 3932542..3932790 + 249 WP_002893037.1 DUF1158 domain-containing protein -
LQV08_RS19265 (3932808) 3932808..3933149 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
LQV08_RS19270 (3933180) 3933180..3934295 - 1116 Protein_3793 MBL fold metallo-hydrolase -
LQV08_RS19275 (3934474) 3934474..3935055 + 582 WP_032419262.1 TetR/AcrR family transcriptional regulator -
LQV08_RS19280 (3935055) 3935055..3935423 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
LQV08_RS19285 (3935543) 3935543..3936196 + 654 WP_032419263.1 oxygen-insensitive NAD(P)H nitroreductase -
LQV08_RS19290 (3936461) 3936461..3936748 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
LQV08_RS19295 (3936741) 3936741..3937058 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQV08_RS19300 (3937243) 3937243..3938286 - 1044 WP_032419264.1 DUF2157 domain-containing protein -
LQV08_RS19305 (3938953) 3938953..3939819 - 867 WP_032419265.1 helix-turn-helix transcriptional regulator -
LQV08_RS19310 (3939928) 3939928..3941355 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T296344 WP_004142563.1 NZ_OW970444:c3937058-3936741 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT296344 WP_004142561.1 NZ_OW970444:c3936748-3936461 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References