Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2764407..2765995 Replicon chromosome
Accession NZ_OW970444
Organism Klebsiella pneumoniae isolate 101

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LQV08_RS13675 Protein ID WP_004184027.1
Coordinates 2764407..2765729 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LQV08_RS13680 Protein ID WP_004176198.1
Coordinates 2765729..2765995 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV08_RS13660 (2759463) 2759463..2761964 + 2502 WP_032439971.1 fimbria/pilus outer membrane usher protein -
LQV08_RS13665 (2761952) 2761952..2762956 + 1005 WP_016946380.1 fimbrial protein -
LQV08_RS13670 (2763098) 2763098..2764390 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LQV08_RS13675 (2764407) 2764407..2765729 - 1323 WP_004184027.1 type II toxin-antitoxin system HipA family toxin Toxin
LQV08_RS13680 (2765729) 2765729..2765995 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LQV08_RS13685 (2766261) 2766261..2766587 - 327 WP_004215084.1 hydroxyisourate hydrolase -
LQV08_RS13690 (2766584) 2766584..2767084 - 501 WP_032418978.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LQV08_RS13695 (2767062) 2767062..2768441 - 1380 WP_032418979.1 nucleobase:cation symporter-2 family protein -
LQV08_RS13700 (2768787) 2768787..2769941 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LQV08_RS13705 (2769922) 2769922..2770845 - 924 WP_032418980.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T296343 WP_004184027.1 NZ_OW970444:c2765729-2764407 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT296343 WP_004176198.1 NZ_OW970444:c2765995-2765729 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References