Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2787775..2789363 Replicon chromosome
Accession NZ_OW970374
Organism Klebsiella pneumoniae isolate 101

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LQV21_RS13780 Protein ID WP_004184027.1
Coordinates 2787775..2789097 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LQV21_RS13785 Protein ID WP_004176198.1
Coordinates 2789097..2789363 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQV21_RS13765 (2782831) 2782831..2785332 + 2502 WP_032439971.1 fimbria/pilus outer membrane usher protein -
LQV21_RS13770 (2785320) 2785320..2786324 + 1005 WP_016946380.1 fimbrial protein -
LQV21_RS13775 (2786466) 2786466..2787758 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LQV21_RS13780 (2787775) 2787775..2789097 - 1323 WP_004184027.1 type II toxin-antitoxin system HipA family toxin Toxin
LQV21_RS13785 (2789097) 2789097..2789363 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LQV21_RS13790 (2789629) 2789629..2789955 - 327 WP_004215084.1 hydroxyisourate hydrolase -
LQV21_RS13795 (2789952) 2789952..2790452 - 501 WP_032418978.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LQV21_RS13800 (2790430) 2790430..2791809 - 1380 WP_032418979.1 nucleobase:cation symporter-2 family protein -
LQV21_RS13805 (2792155) 2792155..2793309 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LQV21_RS13810 (2793290) 2793290..2794213 - 924 WP_032418980.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T296279 WP_004184027.1 NZ_OW970374:c2789097-2787775 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT296279 WP_004176198.1 NZ_OW970374:c2789363-2789097 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References