Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2169092..2169781 Replicon chromosome
Accession NZ_OW969633
Organism Klebsiella aerogenes isolate 57

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LQ131_RS10295 Protein ID WP_042894575.1
Coordinates 2169485..2169781 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQ131_RS10290 Protein ID WP_032711784.1
Coordinates 2169092..2169427 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ131_RS10265 (2164292) 2164292..2164735 - 444 WP_020078629.1 GNAT family N-acetyltransferase -
LQ131_RS10270 (2164916) 2164916..2165899 + 984 WP_015366313.1 zinc transporter ZntB -
LQ131_RS25235 (2166187) 2166187..2166369 + 183 WP_071596126.1 hypothetical protein -
LQ131_RS10275 (2166384) 2166384..2167757 + 1374 WP_230132865.1 ATP-dependent RNA helicase DbpA -
LQ131_RS10280 (2167805) 2167805..2168740 - 936 WP_032711785.1 tRNA 2-thiocytidine(32) synthetase TtcA -
LQ131_RS10285 (2168788) 2168788..2169057 - 270 Protein_2013 tyrosine-type recombinase/integrase -
LQ131_RS10290 (2169092) 2169092..2169427 - 336 WP_032711784.1 HigA family addiction module antitoxin Antitoxin
LQ131_RS10295 (2169485) 2169485..2169781 - 297 WP_042894575.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ131_RS10300 (2170018) 2170018..2170452 - 435 WP_015366316.1 universal stress protein UspF -
LQ131_RS10305 (2170597) 2170597..2171739 - 1143 WP_042894578.1 porin OmpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-96)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-84)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11554.16 Da        Isoelectric Point: 7.4629

>T296145 WP_042894575.1 NZ_OW969633:c2169781-2169485 [Klebsiella aerogenes]
MQNHIGSFRDVWLEEFFLHSAPHKKIPPDIHTTLARKLDIINAAVTYLDLRSPPGNRYEELNGKLEGYSSIRINQQYRLI
FKWVDGKAEDLYLDPHKY

Download         Length: 297 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12694.53 Da        Isoelectric Point: 7.2045

>AT296145 WP_032711784.1 NZ_OW969633:c2169427-2169092 [Klebsiella aerogenes]
MKQATRKPTTVGDILQFEYLEPLDLKINELAEMIHVHRNSVSALVNNNRKLTTDMAFRLSKAFNTTVDFWLNLQAAVDLW
EVENDTRAQEEFSRIVPASKFIASKADKKVA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References