Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3797054..3797672 Replicon chromosome
Accession NZ_OW967966
Organism Escherichia coli isolate 648

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LQ127_RS18655 Protein ID WP_001291435.1
Coordinates 3797454..3797672 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LQ127_RS18650 Protein ID WP_000344800.1
Coordinates 3797054..3797428 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ127_RS18640 (3792143) 3792143..3793336 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ127_RS18645 (3793359) 3793359..3796508 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LQ127_RS18650 (3797054) 3797054..3797428 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LQ127_RS18655 (3797454) 3797454..3797672 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LQ127_RS18660 (3797844) 3797844..3798395 + 552 WP_000102574.1 maltose O-acetyltransferase -
LQ127_RS18665 (3798511) 3798511..3798981 + 471 WP_022645280.1 YlaC family protein -
LQ127_RS18670 (3799145) 3799145..3800695 + 1551 WP_022645279.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LQ127_RS18675 (3800737) 3800737..3801090 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LQ127_RS18685 (3801469) 3801469..3801780 + 312 WP_000409911.1 MGMT family protein -
LQ127_RS18690 (3801811) 3801811..3802383 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295892 WP_001291435.1 NZ_OW967966:3797454-3797672 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT295892 WP_000344800.1 NZ_OW967966:3797054-3797428 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References