Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 144381..144886 Replicon chromosome
Accession NC_021577
Organism Pseudomonas aeruginosa RP73

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag M062_RS00630 Protein ID WP_003083773.1
Coordinates 144381..144662 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag M062_RS00635 Protein ID WP_003083775.1
Coordinates 144659..144886 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M062_RS00605 139632..140981 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
M062_RS00610 141030..141716 + 687 WP_003083762.1 FadR family transcriptional regulator -
M062_RS00615 141817..142551 + 735 WP_003117208.1 GntR family transcriptional regulator -
M062_RS00620 142755..143141 + 387 WP_014602345.1 aegerolysin family protein -
M062_RS00625 143173..144081 - 909 WP_016561475.1 LysR family transcriptional regulator -
M062_RS00630 144381..144662 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
M062_RS00635 144659..144886 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
M062_RS00640 145063..145683 - 621 WP_009314940.1 hypothetical protein -
M062_RS00645 145784..146284 + 501 WP_003112629.1 LEA type 2 family protein -
M062_RS00650 146357..146698 + 342 WP_003101229.1 alkylphosphonate utilization protein -
M062_RS00655 146780..148207 - 1428 WP_003083784.1 GABA permease -
M062_RS00660 148376..149869 - 1494 WP_016561476.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T29579 WP_003083773.1 NC_021577:c144662-144381 [Pseudomonas aeruginosa RP73]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T29579 NC_021577:c144662-144381 [Pseudomonas aeruginosa RP73]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT29579 WP_003083775.1 NC_021577:c144886-144659 [Pseudomonas aeruginosa RP73]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT29579 NC_021577:c144886-144659 [Pseudomonas aeruginosa RP73]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References