Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 456909..457669 Replicon chromosome
Accession NZ_OW704291
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name tacT Uniprot ID Q8Z2B1
Locus tag NBX00_RS02130 Protein ID WP_000533908.1
Coordinates 457184..457669 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag NBX00_RS02125 Protein ID WP_000965889.1
Coordinates 456909..457196 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBX00_RS02105 452314..453225 + 912 WP_001168555.1 glycine--tRNA ligase subunit alpha -
NBX00_RS02110 453235..455304 + 2070 WP_001291805.1 glycine--tRNA ligase subunit beta -
NBX00_RS02115 455694..456122 + 429 Protein_406 IS3 family transposase -
NBX00_RS02120 456264..456731 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
NBX00_RS02125 456909..457196 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
NBX00_RS02130 457184..457669 + 486 WP_000533908.1 GNAT family N-acetyltransferase Toxin
NBX00_RS02135 458040..458579 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
NBX00_RS02140 458755..458967 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NBX00_RS02145 459258..459545 - 288 Protein_412 HTH-type transcriptional regulator -
NBX00_RS02150 459984..460694 + 711 WP_000190524.1 DUF3053 domain-containing protein -
NBX00_RS02155 460744..461718 - 975 WP_000804690.1 glyoxylate/hydroxypyruvate reductase GhrB -
NBX00_RS02160 461937..462599 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17689.38 Da        Isoelectric Point: 9.8719

>T295441 WP_000533908.1 NZ_OW704291:457184-457669 [Salmonella enterica subsp. enterica serovar Typhi]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT295441 WP_000965889.1 NZ_OW704291:456909-457196 [Salmonella enterica subsp. enterica serovar Typhi]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A714MHS9

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References