Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 375379..375907 Replicon chromosome
Accession NZ_OW443151
Organism Vibrio cholerae strain CNRVC190247 isolate YE-NCPHL-18035-PI

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag OC536_RS16105 Protein ID WP_000221354.1
Coordinates 375620..375907 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag OC536_RS16100 Protein ID WP_032477085.1
Coordinates 375379..375630 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OC536_RS16065 (CNRVC190247_03186) 370732..371220 + 489 WP_114717217.1 dual specificity protein phosphatase family protein -
OC536_RS16070 (CNRVC190247_03187) 371395..372267 + 873 WP_000254717.1 DUF3800 domain-containing protein -
OC536_RS16075 (CNRVC190247_03188) 372418..372741 + 324 WP_000248693.1 DUF4144 domain-containing protein -
OC536_RS16080 (CNRVC190247_03189) 372889..373362 + 474 WP_153734401.1 hypothetical protein -
OC536_RS16085 (CNRVC190247_03191) 373405..374582 + 1178 WP_086010043.1 IS3 family transposase -
OC536_RS16090 (CNRVC190247_03192) 374591..374812 - 222 Protein_382 GNAT family N-acetyltransferase -
OC536_RS16095 (CNRVC190247_03193) 374809..375081 - 273 WP_000246253.1 DUF1778 domain-containing protein -
OC536_RS16100 (CNRVC190247_03194) 375379..375630 + 252 WP_032477085.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OC536_RS16105 (CNRVC190247_03195) 375620..375907 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OC536_RS16110 375938..376108 - 171 Protein_386 IS30 family transposase -
OC536_RS16115 (CNRVC190247_03196) 376426..379212 + 2787 Protein_387 alkaline phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island qnrVC4 - 308122..375907 67785
- inside Integron qnrVC4 - 308793..373362 64569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T295420 WP_000221354.1 NZ_OW443151:375620-375907 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9150.31 Da        Isoelectric Point: 4.0334

>AT295420 WP_032477085.1 NZ_OW443151:375379-375630 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGAAIAILNHNKPAAYLVPAETYEYLIDMLEDYELSQIVDSRRADLSQAVEVNI
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure

References