295266

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 62057..62760 Replicon chromosome
Accession NZ_OW052570
Organism Mycobacterium tuberculosis strain Lineage 1.1.2 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag MR177_RS00395 Protein ID WP_003409778.1
Coordinates 62431..62760 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag MR177_RS00390 Protein ID WP_003409780.1
Coordinates 62057..62434 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR177_RS00350 57215..57406 + 192 WP_003409876.1 hypothetical protein -
MR177_RS00355 57427..58329 + 903 WP_003409874.1 hypothetical protein -
MR177_RS00360 58340..58690 + 351 WP_003409871.1 hypothetical protein -
MR177_RS00365 58804..58986 + 183 WP_003409870.1 hypothetical protein -
MR177_RS00370 58979..59380 - 402 WP_003409869.1 hypothetical protein -
MR177_RS00375 59444..59896 + 453 WP_003899095.1 lipoprotein -
MR177_RS00380 60051..61415 - 1365 WP_031673929.1 HNH endonuclease signature motif containing protein -
MR177_RS00385 61470..62060 + 591 WP_003409784.1 SEC-C metal-binding domain-containing protein -
MR177_RS00390 62057..62434 + 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
MR177_RS00395 62431..62760 + 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MR177_RS00400 62970..63740 - 771 WP_003409775.1 SDR family oxidoreductase -
MR177_RS00405 63737..64798 - 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
MR177_RS00410 64795..65310 - 516 WP_003409718.1 flavin reductase family protein -
MR177_RS00415 65307..66377 - 1071 WP_003899091.1 epoxide hydrolase EphB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T295266 WP_003409778.1 NZ_OW052570:62431-62760 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT295266 WP_003409780.1 NZ_OW052570:62057-62434 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References