Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3924380..3925956 Replicon chromosome
Accession NZ_OU659204
Organism Providencia alcalifaciens strain 2019-04-29291-1-1 isolate 2019-04-29291-1-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LDO73_RS17945 Protein ID WP_224059637.1
Coordinates 3924380..3925699 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LDO73_RS17950 Protein ID WP_224059638.1
Coordinates 3925699..3925956 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO73_RS17935 (NVI2019_GHJFPKLH_03595) 3920318..3923365 - 3048 WP_282560708.1 formate dehydrogenase-N subunit alpha -
LDO73_RS17940 (NVI2019_GHJFPKLH_03597) 3923541..3924371 + 831 WP_224059636.1 formate dehydrogenase accessory sulfurtransferase FdhD -
LDO73_RS17945 (NVI2019_GHJFPKLH_03598) 3924380..3925699 - 1320 WP_224059637.1 type II toxin-antitoxin system HipA family toxin Toxin
LDO73_RS17950 (NVI2019_GHJFPKLH_03599) 3925699..3925956 - 258 WP_224059638.1 helix-turn-helix domain-containing protein Antitoxin
LDO73_RS17955 (NVI2019_GHJFPKLH_03600) 3926119..3927483 - 1365 WP_224059639.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
LDO73_RS17960 (NVI2019_GHJFPKLH_03601) 3927595..3929256 - 1662 WP_224059640.1 membrane protein insertase YidC -
LDO73_RS17965 (NVI2019_GHJFPKLH_03602) 3929259..3929519 - 261 WP_006660611.1 membrane protein insertion efficiency factor YidD -
LDO73_RS17970 (NVI2019_GHJFPKLH_03603) 3929483..3929842 - 360 WP_006660612.1 ribonuclease P protein component -
LDO73_RS17975 (NVI2019_GHJFPKLH_03604) 3929861..3930004 - 144 WP_004906236.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49964.22 Da        Isoelectric Point: 6.6688

>T294830 WP_224059637.1 NZ_OU659204:c3925699-3924380 [Providencia alcalifaciens]
MAILHVYMNGYLVGEFIHSSTGAHQFKYDNHWLEMPGTRPISLSMPLQHKEYKGDEVYNFFDNLLPDNIEIRNRIVSRHQ
ANSNQPFDLLSKIGQDSVGALQLVPAGQTVSNVKQIEYKRLSTEKLEKILTGYKANIPLGMIEEEDDFRISIAGAQEKTA
LLNLDRYWCLPLNATPTTHIIKLPIGKIESHSYSIDMSDSVENEHLCLLIAKAFGLDVPHSFILNVGKIKALAVERFDRK
YSSDYSWIMRLPQEDFCQTLNVSPAIKYQSHGGPGIQDIMDYLLGSINAEKDRYQFMKSQVLFWLLAATDGHAKNFSLFI
ESEGRYQLTPFYDILSMYPSYGGRGLNPRDAKLAMGLKGKKGIKYEIEQIFPRHFFATAKAVGFDRTEMEKILIEFDEQM
ESVITKVSEQLPTDFPEHIANSILSGLHQKAARLKKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9646.88 Da        Isoelectric Point: 9.0396

>AT294830 WP_224059638.1 NZ_OU659204:c3925956-3925699 [Providencia alcalifaciens]
MKITNTRQLSAYMKDVRETKKLSQSKVASKVGIRQDTVSSFECSPDSTKLETFFKILSALNLELDIKPRNESGSSNTDSG
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References