Detailed information of TA system TA294309

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2098282..2098861
• Replicon: chromosome
• Accession: NZ_LT992475
• Organism: Staphylococcus aureus isolate 20_LA_415

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DXE41_RS11220
• Protein ID: WP_001025401.1
• Coordinates: 2098616..2098861 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2098282..2098647 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE41_RS11180	2095025..2095582	-	558	WP_000645042.1	DUF2815 family protein	-
DXE41_RS11185	2095608..2096774	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
DXE41_RS11190	2096771..2097133	-	363	WP_031775157.1	hypothetical protein	-
DXE41_RS11195	2097148..2097471	-	324	WP_000174994.1	hypothetical protein	-
DXE41_RS11200	2097550..2097711	-	162	WP_001285963.1	DUF1270 family protein	-
DXE41_RS11205	2097724..2097987	-	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
DXE41_RS11210	2098012..2098227	-	216	WP_001036302.1	hypothetical protein	-
DXE41_RS11215	2098282..2098647	+	366	WP_001128433.1	hypothetical protein	Antitoxin
DXE41_RS11220	2098616..2098861	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DXE41_RS11225	2098877..2099125	-	249	WP_000272860.1	helix-turn-helix domain-containing protein	-
DXE41_RS11230	2099289..2099612	+	324	WP_001260485.1	helix-turn-helix domain-containing protein	-
DXE41_RS11235	2099625..2100086	+	462	WP_031838007.1	toxin	-
DXE41_RS11240	2100104..2100538	+	435	WP_000755718.1	hypothetical protein	-
DXE41_RS11245	2100567..2100962	+	396	WP_000449655.1	hypothetical protein	-
DXE41_RS11250	2101052..2101198	+	147	WP_074370993.1	hypothetical protein	-
DXE41_RS11255	2101195..2101809	-	615	WP_000191466.1	hypothetical protein	-
DXE41_RS11260	2101935..2103140	+	1206	WP_000264745.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2059099..2103140	44041

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294309 WP_001025401.1 NZ_LT992475:c2098861-2098616 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294309 NZ_LT992475:2098282-2098647 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin