Detailed information of TA system TA294243

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2158331..2158638
• Replicon: chromosome
• Accession: NZ_LT992471
• Organism: Staphylococcus aureus isolate 17_LA_343

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DXE46_RS11155
• Protein ID: WP_011447039.1
• Coordinates: 2158462..2158638 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2158331..2158470 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE46_RS11110	2154166..2154413	+	248	Protein_2058	sphingomyelin phosphodiesterase	-
DXE46_RS11115	2154735..2154914	+	180	WP_000669789.1	hypothetical protein	-
DXE46_RS11125	2155225..2155485	+	261	WP_001791826.1	hypothetical protein	-
DXE46_RS11130	2155538..2155888	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
DXE46_RS11135	2156547..2157038	-	492	WP_000919350.1	staphylokinase	-
DXE46_RS11140	2157229..2157984	-	756	WP_064131634.1	CHAP domain-containing protein	-
DXE46_RS11145	2157996..2158250	-	255	WP_000611512.1	phage holin	-
DXE46_RS11150	2158302..2158409	+	108	WP_001791821.1	hypothetical protein	-
-	2158331..2158470	+	140	NuclAT_0	-	Antitoxin
-	2158331..2158470	+	140	NuclAT_0	-	Antitoxin
-	2158331..2158470	+	140	NuclAT_0	-	Antitoxin
-	2158331..2158470	+	140	NuclAT_0	-	Antitoxin
DXE46_RS11155	2158462..2158638	-	177	WP_011447039.1	putative holin-like toxin	Toxin
DXE46_RS11160	2158788..2159084	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
DXE46_RS11165	2159142..2159429	-	288	WP_001040261.1	hypothetical protein	-
DXE46_RS11170	2159476..2159628	-	153	WP_001153681.1	hypothetical protein	-
DXE46_RS11175	2159618..2163402	-	3785	Protein_2070	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	2155538..2205448	49910

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T294243 WP_011447039.1 NZ_LT992471:c2158638-2158462 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294243 NZ_LT992471:2158331-2158470 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin