Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 8789994..8790670 Replicon chromosome
Accession NC_021191
Organism Actinoplanes sp. N902-109

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag L083_RS37825 Protein ID WP_198029259.1
Coordinates 8789994..8790359 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L083_RS37830 Protein ID WP_015625864.1
Coordinates 8790356..8790670 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L083_RS37810 8785759..8786379 + 621 WP_015625860.1 hypothetical protein -
L083_RS37815 8786425..8789085 + 2661 WP_041832959.1 alpha/beta fold hydrolase -
L083_RS37820 8789082..8789927 + 846 WP_015625862.1 ABC transporter permease subunit -
L083_RS37825 8789994..8790359 + 366 WP_198029259.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L083_RS37830 8790356..8790670 + 315 WP_015625864.1 helix-turn-helix transcriptional regulator Antitoxin
L083_RS37835 8790671..8791498 - 828 WP_015625868.1 aminoglycoside phosphotransferase family protein -
L083_RS37840 8791495..8792280 - 786 WP_015625865.1 DeoR/GlpR family DNA-binding transcription regulator -
L083_RS37845 8792462..8793373 + 912 WP_015625866.1 SIS domain-containing protein -
L083_RS37850 8793416..8794339 + 924 WP_015625867.1 ROK family protein -
L083_RS37855 8794336..8795433 + 1098 WP_015625869.1 N-acetylglucosamine-6-phosphate deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-108)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-92)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13568.39 Da        Isoelectric Point: 6.4030

>T29420 WP_198029259.1 NC_021191:8789994-8790359 [Actinoplanes sp. N902-109]
IRTTAEVRDWLRSLRQADSETYRTVNIALDMLAEIGPGLGRPLVDSVRGSTIGNLKELRPRSGRDIAVRVLFVFDPWSQA
VLLVAGNKAGAWTRWYEVAVPEAEKAYEGWLTAEEERRQGA

Download         Length: 366 bp

>T29420 NC_021191:8789994-8790359 [Actinoplanes sp. N902-109]
ATCAGGACGACAGCCGAGGTACGCGATTGGCTTCGTTCTCTTCGCCAGGCCGACTCGGAGACATATCGCACGGTGAACAT
CGCTCTCGACATGTTGGCGGAGATCGGTCCGGGGCTGGGCCGACCGCTCGTCGACTCGGTGCGCGGATCGACCATCGGCA
ACCTCAAGGAGTTGCGGCCGAGATCCGGGCGCGACATCGCCGTCCGCGTCCTGTTCGTATTCGATCCCTGGTCGCAGGCG
GTTCTACTGGTGGCCGGCAACAAAGCCGGCGCTTGGACGCGGTGGTACGAAGTCGCTGTTCCTGAGGCGGAGAAAGCCTA
CGAGGGGTGGCTGACCGCCGAGGAGGAACGGAGGCAAGGGGCATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11750.12 Da        Isoelectric Point: 4.4840

>AT29420 WP_015625864.1 NC_021191:8790356-8790670 [Actinoplanes sp. N902-109]
MTEFYDWADIRAELHDGDDDALAAERARTEAWISAFHLAEERKRLGLTQRQVAELMGVTPGRVSQIENGDLDVNEVATLS
RYAKALGARLRIIFDYGDDLRQIA

Download         Length: 315 bp

>AT29420 NC_021191:8790356-8790670 [Actinoplanes sp. N902-109]
ATGACCGAGTTCTACGACTGGGCGGACATCCGCGCTGAACTGCACGACGGGGACGATGATGCCCTCGCGGCCGAACGGGC
CCGGACCGAGGCGTGGATCAGCGCGTTTCACCTCGCCGAGGAACGCAAGCGCCTGGGGTTGACGCAGCGACAGGTGGCCG
AGCTCATGGGAGTGACTCCTGGCCGGGTGAGCCAGATCGAGAACGGGGACCTGGACGTCAACGAGGTGGCCACGCTCAGC
AGATACGCCAAGGCGCTGGGCGCCCGGTTGCGGATCATCTTCGACTACGGCGACGATCTTCGTCAGATCGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References