Detailed information of TA system TA294191

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 509486..510065
• Replicon: chromosome
• Accession: NZ_LT992468
• Organism: Staphylococcus aureus isolate 12_LA_293

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DXE47_RS02940
• Protein ID: WP_001025401.1
• Coordinates: 509820..510065 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	509486..509851 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE47_RS02900	506228..506782	-	555	WP_000647288.1	DUF2815 family protein	-
DXE47_RS02905	506809..507975	-	1167	WP_031794951.1	DUF2800 domain-containing protein	-
DXE47_RS02910	507972..508334	-	363	WP_000985976.1	hypothetical protein	-
DXE47_RS02915	508349..508672	-	324	WP_000174994.1	hypothetical protein	-
DXE47_RS02920	508752..508913	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
DXE47_RS02925	508926..509189	-	264	WP_001596347.1	helix-turn-helix domain-containing protein	-
DXE47_RS02930	509216..509431	-	216	WP_001097552.1	hypothetical protein	-
DXE47_RS02935	509486..509851	+	366	WP_001128433.1	hypothetical protein	Antitoxin
DXE47_RS02940	509820..510065	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DXE47_RS02945	510132..510512	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
DXE47_RS02950	510499..510696	-	198	WP_001148860.1	hypothetical protein	-
DXE47_RS02955	510766..510978	+	213	WP_000362644.1	hypothetical protein	-
DXE47_RS15320	511019..511168	-	150	WP_000771849.1	hypothetical protein	-
DXE47_RS02960	511183..511626	-	444	WP_000435357.1	hypothetical protein	-
DXE47_RS02965	511644..511868	-	225	WP_000333485.1	DUF739 family protein	-
DXE47_RS02970	512030..512410	+	381	WP_001089477.1	helix-turn-helix domain-containing protein	-
DXE47_RS02975	512432..512890	+	459	WP_001558059.1	hypothetical protein	-
DXE47_RS02980	512908..513342	+	435	WP_000755718.1	hypothetical protein	-
DXE47_RS02985	513371..513766	+	396	WP_001558060.1	hypothetical protein	-
DXE47_RS02990	513856..514002	+	147	WP_001013104.1	hypothetical protein	-
DXE47_RS02995	513999..514613	-	615	WP_031863779.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294191 WP_001025401.1 NZ_LT992468:c510065-509820 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294191 NZ_LT992468:509486-509851 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin