Detailed information of TA system TA294136

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 581499..581837
• Replicon: chromosome
• Accession: NZ_LT992464
• Organism: Staphylococcus aureus isolate 3_LA_115

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: DXE56_RS03175
• Protein ID: WP_114621363.1
• Coordinates: 581499..581675 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	581663..581837 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE56_RS03155	576734..580519	+	3786	WP_062832899.1	hypothetical protein	-
DXE56_RS03160	580509..580661	+	153	WP_001153681.1	hypothetical protein	-
DXE56_RS03165	580708..580995	+	288	WP_001040261.1	hypothetical protein	-
DXE56_RS03170	581053..581349	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
DXE56_RS03175	581499..581675	+	177	WP_114621363.1	putative holin-like toxin	Toxin
-	581663..581837	-	175	-	-	Antitoxin
DXE56_RS03185	581887..582141	+	255	WP_000611512.1	phage holin	-
DXE56_RS03190	582153..582908	+	756	WP_000861038.1	CHAP domain-containing protein	-
DXE56_RS03195	583098..583589	+	492	WP_000920041.1	staphylokinase	-
DXE56_RS03210	584190..584524	+	335	Protein_592	SH3 domain-containing protein	-
DXE56_RS03215	584619..585068	-	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
DXE56_RS03220	585751..586101	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
DXE56_RS03225	586154..586414	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	535602..586101	50499

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6881.51 Da
• Isoelectric Point: 10.6777

>T294136 WP_114621363.1 NZ_LT992464:581499-581675 [Staphylococcus aureus]
MDRWWLSEYKEMVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 175 bp

>AT294136 NZ_LT992464:c581837-581663 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin