Detailed information of TA system TA294099

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 728272..728579
• Replicon: chromosome
• Accession: NZ_LT992462
• Organism: Staphylococcus aureus isolate 5_3949

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DXE65_RS03610
• Protein ID: WP_011447039.1
• Coordinates: 728403..728579 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	728272..728411 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE65_RS03565	723610..723870	+	261	WP_001791826.1	hypothetical protein	-
DXE65_RS03570	723923..724273	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
DXE65_RS03575	724959..725408	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
DXE65_RS03580	725503..725838	-	336	Protein_675	SH3 domain-containing protein	-
DXE65_RS03590	726488..726979	-	492	WP_000919350.1	staphylokinase	-
DXE65_RS03595	727170..727925	-	756	WP_000861038.1	CHAP domain-containing protein	-
DXE65_RS03600	727937..728191	-	255	WP_000611512.1	phage holin	-
DXE65_RS03605	728243..728350	+	108	WP_001791821.1	hypothetical protein	-
-	728272..728411	+	140	NuclAT_0	-	Antitoxin
-	728272..728411	+	140	NuclAT_0	-	Antitoxin
-	728272..728411	+	140	NuclAT_0	-	Antitoxin
-	728272..728411	+	140	NuclAT_0	-	Antitoxin
DXE65_RS03610	728403..728579	-	177	WP_011447039.1	putative holin-like toxin	Toxin
DXE65_RS03615	728688..729461	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
DXE65_RS03625	729882..730256	-	375	WP_000340977.1	hypothetical protein	-
DXE65_RS03630	730312..730599	-	288	WP_001040259.1	hypothetical protein	-
DXE65_RS03635	730646..730798	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp / scn / chp / sak / sea	690310..795503	105193

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T294099 WP_011447039.1 NZ_LT992462:c728579-728403 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 140 bp

>AT294099 NZ_LT992462:728272-728411 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin