Detailed information of TA system TA294093

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1324331..1324910
• Replicon: chromosome
• Accession: NZ_LT992461
• Organism: Staphylococcus aureus isolate 8_LA_272

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DXE60_RS06985
• Protein ID: WP_001025401.1
• Coordinates: 1324331..1324576 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1324545..1324910 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE60_RS06945	1320052..1321257	-	1206	WP_000264745.1	site-specific integrase	-
DXE60_RS06950	1321383..1321997	+	615	WP_000191466.1	hypothetical protein	-
DXE60_RS06955	1321994..1322140	-	147	WP_074370993.1	hypothetical protein	-
DXE60_RS06960	1322230..1322625	-	396	WP_000449655.1	hypothetical protein	-
DXE60_RS06965	1322654..1323088	-	435	WP_000755718.1	hypothetical protein	-
DXE60_RS06970	1323106..1323567	-	462	WP_031838007.1	toxin	-
DXE60_RS06975	1323580..1323903	-	324	WP_001260485.1	helix-turn-helix domain-containing protein	-
DXE60_RS06980	1324067..1324315	+	249	WP_000272860.1	helix-turn-helix domain-containing protein	-
DXE60_RS06985	1324331..1324576	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DXE60_RS06990	1324545..1324910	-	366	WP_001128433.1	hypothetical protein	Antitoxin
DXE60_RS06995	1324965..1325180	+	216	WP_001036302.1	hypothetical protein	-
DXE60_RS07000	1325205..1325468	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
DXE60_RS07005	1325481..1325642	+	162	WP_001285963.1	DUF1270 family protein	-
DXE60_RS07010	1325721..1326044	+	324	WP_000174994.1	hypothetical protein	-
DXE60_RS07015	1326059..1326421	+	363	WP_031775157.1	hypothetical protein	-
DXE60_RS07020	1326418..1327584	+	1167	WP_000762547.1	DUF2800 domain-containing protein	-
DXE60_RS07025	1327610..1328167	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1320052..1364093	44041

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294093 WP_001025401.1 NZ_LT992461:1324331-1324576 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294093 NZ_LT992461:c1324910-1324545 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin