Detailed information of TA system TA294047

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2572502..2573081
• Replicon: chromosome
• Accession: NZ_LT992456
• Organism: Staphylococcus aureus isolate 1_1439

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DXE58_RS13360
• Protein ID: WP_001025401.1
• Coordinates: 2572502..2572747 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2572716..2573081 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXE58_RS13310	2567827..2568441	+	615	WP_001568848.1	phage protein	-
DXE58_RS13315	2568438..2568584	-	147	WP_001795334.1	hypothetical protein	-
DXE58_RS13320	2568814..2569398	-	585	WP_000825948.1	hypothetical protein	-
DXE58_RS13325	2569416..2569877	-	462	WP_000525004.1	hypothetical protein	-
DXE58_RS13330	2569890..2570204	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
DXE58_RS13335	2570356..2570592	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
DXE58_RS13340	2570606..2571382	+	777	WP_001148544.1	Rha family transcriptional regulator	-
DXE58_RS15010	2571411..2571560	+	150	WP_000771849.1	hypothetical protein	-
DXE58_RS13345	2571601..2571813	-	213	WP_000362644.1	hypothetical protein	-
DXE58_RS13350	2571883..2572080	+	198	WP_001148860.1	hypothetical protein	-
DXE58_RS13355	2572067..2572447	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
DXE58_RS13360	2572502..2572747	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DXE58_RS13365	2572716..2573081	-	366	WP_001128433.1	hypothetical protein	Antitoxin
DXE58_RS13370	2573136..2573351	+	216	WP_001097552.1	hypothetical protein	-
DXE58_RS13375	2573376..2573639	+	264	WP_016187436.1	helix-turn-helix domain-containing protein	-
DXE58_RS13380	2573652..2573813	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
DXE58_RS13385	2573892..2574215	+	324	WP_000174994.1	hypothetical protein	-
DXE58_RS13390	2574230..2574592	+	363	WP_031863778.1	hypothetical protein	-
DXE58_RS13395	2574589..2575755	+	1167	WP_031775793.1	DUF2800 domain-containing protein	-
DXE58_RS13400	2575782..2576336	+	555	WP_000647288.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T294047 WP_001025401.1 NZ_LT992456:2572502-2572747 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT294047 NZ_LT992456:c2573081-2572716 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin