Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4111984..4112719 Replicon chromosome
Accession NZ_LT962688
Organism Methylorubrum extorquens strain TK 0001

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag TK0001_RS27780 Protein ID WP_197707620.1
Coordinates 4112282..4112719 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1W6RKV4
Locus tag TK0001_RS19375 Protein ID WP_056462529.1
Coordinates 4111984..4112268 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TK0001_RS19355 4107417..4109840 - 2424 WP_101476128.1 phenylalanine--tRNA ligase subunit beta -
TK0001_RS19360 4109905..4110984 - 1080 WP_015950513.1 phenylalanine--tRNA ligase subunit alpha -
TK0001_RS19365 4111169..4111534 - 366 WP_003602669.1 50S ribosomal protein L20 -
TK0001_RS19370 4111587..4111790 - 204 WP_003602670.1 50S ribosomal protein L35 -
TK0001_RS19375 4111984..4112268 - 285 WP_056462529.1 HigA family addiction module antidote protein Antitoxin
TK0001_RS27780 4112282..4112719 - 438 WP_197707620.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TK0001_RS19385 4112815..4113948 + 1134 WP_015822208.1 glycosyltransferase family 4 protein -
TK0001_RS19390 4114107..4116443 + 2337 WP_056506981.1 amylo-alpha-1,6-glucosidase -
TK0001_RS19395 4116635..4117165 - 531 WP_012253214.1 translation initiation factor IF-3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(53-145)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-79)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 16455.52 Da        Isoelectric Point: 7.6479

>T293866 WP_197707620.1 NZ_LT962688:c4112719-4112282 [Methylorubrum extorquens]
MVPPRAWGERQSLQPHGIPVFHICWPATQAGSRGCGCRASDGIVRCPYNDDLIILSYRNRDTEALDVHGVCHRRWRSFQA
AAGRKLDMLNAASVVSDLRSPPGNRLEKLSGDREGQWSIRINDQWRICFRWDGSGPEDVEIVDYH

Download         Length: 438 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10570.11 Da        Isoelectric Point: 7.2787

>AT293866 WP_056462529.1 NZ_LT962688:c4112268-4111984 [Methylorubrum extorquens]
MPRIRSHPGEILLEEYLRPLEMSANALAKAIEVPANRISELLRGRRGMTADTACRLGRFFGTTPEFWMSLQTAHDLSRAV
AEHDYSTLRALESA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1W6RKV4

References