Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2604213..2604808 Replicon chromosome
Accession NZ_LT962688
Organism Methylorubrum extorquens strain TK 0001

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag TK0001_RS12410 Protein ID WP_056499989.1
Coordinates 2604518..2604808 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A1W6RNQ5
Locus tag TK0001_RS12405 Protein ID WP_056499991.1
Coordinates 2604213..2604515 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TK0001_RS12385 2600292..2601320 + 1029 WP_056118396.1 alpha/beta hydrolase -
TK0001_RS12390 2601429..2602040 + 612 WP_101475782.1 phosphatase PAP2 family protein -
TK0001_RS12395 2602226..2602453 - 228 WP_003603049.1 hypothetical protein -
TK0001_RS12400 2602623..2604191 + 1569 Protein_2452 glutamine-hydrolyzing GMP synthase -
TK0001_RS12405 2604213..2604515 - 303 WP_056499991.1 putative addiction module antidote protein Antitoxin
TK0001_RS12410 2604518..2604808 - 291 WP_056499989.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TK0001_RS12415 2605141..2605974 + 834 WP_085857377.1 ABC transporter substrate-binding protein -
TK0001_RS12420 2605971..2607011 + 1041 WP_101475783.1 iron ABC transporter permease -
TK0001_RS12425 2607008..2607823 + 816 WP_085857376.1 ABC transporter ATP-binding protein -
TK0001_RS12430 2607798..2608754 + 957 WP_085857375.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(4-94)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10689.37 Da        Isoelectric Point: 10.2219

>T293865 WP_056499989.1 NZ_LT962688:c2604808-2604518 [Methylorubrum extorquens]
MPTIRRTSVFQTWIDDLRDVRAVARIAKRIDRLALGNPGDVKPVGDGVSEMRIDYGPGYRIYFTAQGKQIVILLCGGDKS
SQERDIRAAKALAKEL

Download         Length: 291 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10931.42 Da        Isoelectric Point: 5.5368

>AT293865 WP_056499991.1 NZ_LT962688:c2604515-2604213 [Methylorubrum extorquens]
MALETQPYDSAEHLKTPEHIAAYLDAVLEDNDPALLAHALGVIARARGMTQIAQDVGRSREQLYRTLSDKGNPQLDTLMG
VLKSLGLRLSVHPVDVERSA

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1W6RNQ5

References