Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1974000..1974563 Replicon chromosome
Accession NZ_LT906470
Organism Veillonella rodentium strain NCTC12018

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CKV62_RS09105 Protein ID WP_095066624.1
Coordinates 1974000..1974176 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CKV62_RS09110 Protein ID WP_095066625.1
Coordinates 1974186..1974563 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV62_RS09075 1969061..1970356 - 1296 WP_095066618.1 adenylosuccinate lyase -
CKV62_RS09080 1970682..1971089 + 408 WP_095066619.1 CAAX protease -
CKV62_RS09085 1971152..1971823 - 672 WP_095066620.1 hypothetical protein -
CKV62_RS09090 1971883..1972752 - 870 WP_095066621.1 hypothetical protein -
CKV62_RS09095 1972756..1973160 - 405 WP_095066622.1 biopolymer transporter ExbD -
CKV62_RS09100 1973157..1973762 - 606 WP_095066623.1 MotA/TolQ/ExbB proton channel family protein -
CKV62_RS09105 1974000..1974176 + 177 WP_095066624.1 type II toxin-antitoxin system HicA family toxin Toxin
CKV62_RS09110 1974186..1974563 + 378 WP_095066625.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CKV62_RS09115 1974759..1976012 - 1254 WP_095066626.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
CKV62_RS09120 1976005..1978194 - 2190 WP_095066627.1 methylmalonyl-CoA mutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-103)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6620.86 Da        Isoelectric Point: 11.0818

>T293735 WP_095066624.1 NZ_LT906470:1974000-1974176 [Veillonella rodentium]
MKDKDLLKLLQKNGWKDVRQRGSYHRLKKGDKVEVITVHGRDVPAGLLNAILKRTGLI

Download         Length: 177 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13776.70 Da        Isoelectric Point: 4.3023

>AT293735 WP_095066625.1 NZ_LT906470:1974186-1974563 [Veillonella rodentium]
MKFIYPAVIHDDGDGLWAEFPDLEYSSSTGATLTELLTNAQEAMELFILGALEDGGTLPEATSIRNLPCTKSTYPTLVQT
DIDLAKNSRSVKKTLTIPAWLNERALAKNLNFSQILQEALVEKTM

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References