Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2803753..2804996 Replicon chromosome
Accession NZ_LT632614
Organism Legionella pneumophila strain ST62 isolate ST62

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag BT141_RS12860 Protein ID WP_042754550.1
Coordinates 2804058..2804996 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag BT141_RS12855 Protein ID WP_027224429.1
Coordinates 2803753..2804061 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BT141_RS12830 2799426..2799623 - 198 WP_014842401.1 hypothetical protein -
BT141_RS12835 2799643..2800869 - 1227 WP_015961555.1 MFS transporter -
BT141_RS12840 2801505..2801978 + 474 WP_027224431.1 hypothetical protein -
BT141_RS12845 2802168..2803085 + 918 WP_042754552.1 LysR family transcriptional regulator -
BT141_RS12850 2803529..2803756 + 228 WP_013101792.1 helix-turn-helix transcriptional regulator -
BT141_RS12855 2803753..2804061 + 309 WP_027224429.1 HipA N-terminal domain-containing protein Antitoxin
BT141_RS12860 2804058..2804996 + 939 WP_042754550.1 HipA domain-containing protein Toxin
BT141_RS12865 2805159..2805869 - 711 WP_027225948.1 outer membrane beta-barrel protein -
BT141_RS12875 2806352..2806645 - 294 WP_042754549.1 SNARE domain-containing protein -
BT141_RS12880 2806673..2807575 - 903 WP_042754548.1 hypothetical protein -
BT141_RS12885 2807738..2809192 + 1455 WP_027225951.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-279)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36063.60 Da        Isoelectric Point: 8.9515

>T293405 WP_042754550.1 NZ_LT632614:2804058-2804996 [Legionella pneumophila]
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKTSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAIIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITRDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
EKNNLTKSDFFNYFAVEKLGLNQNVINGIAQEFHQAIPEWRELISFSFLSQPMQEKYLQLLDQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11586.38 Da        Isoelectric Point: 4.5859

>AT293405 WP_027224429.1 NZ_LT632614:2803753-2804061 [Legionella pneumophila]
MRKAYVSVNGIKAGILEELQSGKYQFSYFDDYHGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLIIVGQDVVGAVTIEEIR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References