Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 154271..154896 Replicon plasmid 2
Accession NZ_LS992167
Organism Escherichia coli isolate Escherichia coli str. TO6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ECTO6_RS24775 Protein ID WP_000911324.1
Coordinates 154498..154896 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag ECTO6_RS24770 Protein ID WP_000450532.1
Coordinates 154271..154498 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO6_RS24770 154271..154498 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
ECTO6_RS24775 154498..154896 + 399 WP_000911324.1 tRNA(fMet)-specific endonuclease VapC Toxin
ECTO6_RS24780 154905..157058 - 2154 WP_000009350.1 type IV conjugative transfer system coupling protein TraD -
ECTO6_RS24790 157311..158042 - 732 WP_000850422.1 complement resistance protein TraT -
ECTO6_RS24795 158067..158588 - 522 WP_000632670.1 conjugal transfer entry exclusion protein TraS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD / tet(A) / mph(B) / sul1 / qacE / ant(3'')-Ia / dfrA1 / aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B / catA1 iroN / iroE / iroD / iroC / iroB 1..174857 174857


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14800.09 Da        Isoelectric Point: 7.8604

>T292727 WP_000911324.1 NZ_LS992167:154498-154896 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMEVIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELALQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT292727 WP_000450532.1 NZ_LS992167:154271-154498 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References