Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1604287..1604876 Replicon chromosome
Accession NZ_LS483438
Organism Haemophilus influenzae strain NCTC12975

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag DQN45_RS08010 Protein ID WP_005653200.1
Coordinates 1604628..1604876 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag DQN45_RS08005 Protein ID WP_005653201.1
Coordinates 1604287..1604631 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN45_RS07990 1599510..1600904 - 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -
DQN45_RS07995 1600948..1601562 + 615 WP_042602710.1 riboflavin synthase -
DQN45_RS08000 1601634..1604243 - 2610 WP_042593851.1 aminopeptidase N -
DQN45_RS08005 1604287..1604631 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DQN45_RS08010 1604628..1604876 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
DQN45_RS08015 1605047..1605541 + 495 WP_042593849.1 5-(carboxyamino)imidazole ribonucleotide mutase -
DQN45_RS08020 1605611..1606699 + 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
DQN45_RS08025 1606839..1608029 + 1191 WP_005657030.1 aspartate/tyrosine/aromatic aminotransferase -
DQN45_RS08030 1608136..1608762 - 627 WP_011272462.1 energy-coupling factor ABC transporter ATP-binding protein -
DQN45_RS08035 1608764..1609396 - 633 WP_042593846.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T292571 WP_005653200.1 NZ_LS483438:c1604876-1604628 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT292571 WP_005653201.1 NZ_LS483438:c1604631-1604287 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References