292523

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2678653..2679893 Replicon chromosome
Accession NZ_LS483412
Organism Legionella pneumophila subsp. pascullei strain NCTC12272

Toxin (Protein)


Gene name HipT Uniprot ID A0A140J6I8
Locus tag DQN66_RS12130 Protein ID WP_027222482.1
Coordinates 2678958..2679893 (+) Length 312 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A140J6I7
Locus tag DQN66_RS12125 Protein ID WP_027222481.1
Coordinates 2678653..2678961 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN66_RS12090 2674125..2674985 + 861 WP_011947276.1 DUF2608 domain-containing protein -
DQN66_RS12095 2675335..2675634 - 300 WP_027222477.1 hypothetical protein -
DQN66_RS12100 2675645..2675956 - 312 WP_011947278.1 cupin -
DQN66_RS12105 2675947..2676228 - 282 WP_050598290.1 hypothetical protein -
DQN66_RS12110 2676404..2676877 + 474 WP_027222478.1 hypothetical protein -
DQN66_RS12115 2677067..2677984 + 918 WP_027222479.1 LysR family transcriptional regulator -
DQN66_RS12120 2678429..2678656 + 228 WP_027222480.1 helix-turn-helix transcriptional regulator -
DQN66_RS12125 2678653..2678961 + 309 WP_027222481.1 HipA N-terminal domain-containing protein Antitoxin
DQN66_RS12130 2678958..2679893 + 936 WP_027222482.1 HipA domain-containing protein Toxin
DQN66_RS12140 2680195..2681340 + 1146 WP_027222483.1 hypothetical protein -
DQN66_RS12145 2681350..2682537 - 1188 WP_061773169.1 fatty acid desaturase -
DQN66_RS12150 2682662..2682829 - 168 WP_011214444.1 DUF3309 domain-containing protein -
DQN66_RS15830 2682941..2683114 + 174 WP_158272786.1 hypothetical protein -
DQN66_RS12155 2683286..2683642 + 357 WP_027222484.1 hypothetical protein -
DQN66_RS12160 2683683..2684615 - 933 WP_027222485.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-275)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 312 a.a.        Molecular weight: 36037.79 Da        Isoelectric Point: 9.3028

>T292523 WP_027222482.1 NZ_LS483412:2678958-2679893 [Legionella pneumophila subsp. pascullei]
MKRCPITYERISDQENYSQRGLYLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSANLKIKEGCFEIVDQNG
HYILKPQSDVYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIEVVEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLKYFAVEKLGLNQKIIDGIVQEFHQIIPEWRKLVGFSFLSQQMQEKYLQLLEQRCKQLNFF

Download         Length: 936 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11664.54 Da        Isoelectric Point: 4.7719

>AT292523 WP_027222481.1 NZ_LS483412:2678653-2678961 [Legionella pneumophila subsp. pascullei]
MRKAYVSVNGIKAGILEELQGGKYQFTYFDDYQGAPVSLTMPLKNKVYYFDVFPPFFEGLLPEGIMLEALLRKYKIDRND
YFGQLIIVGQDVVGAVTIEELR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A140J6I8

Antitoxin

Source ID Structure
AlphaFold DB A0A140J6I7

References