Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1854189..1854691 Replicon chromosome
Accession NZ_LS483296
Organism Escherichia coli strain NCTC9966

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag DQM96_RS09460 Protein ID WP_000767829.1
Coordinates 1854437..1854691 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag DQM96_RS09455 Protein ID WP_001259255.1
Coordinates 1854189..1854440 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM96_RS09425 1849368..1850435 - 1068 WP_000080088.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
DQM96_RS09430 1850435..1851505 - 1071 WP_000108969.1 histidinol-phosphate transaminase -
DQM96_RS09435 1851502..1852806 - 1305 WP_021823828.1 histidinol dehydrogenase -
DQM96_RS09440 1852812..1853711 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
DQM96_RS09450 1853857..1853907 - 51 WP_001364200.1 his operon leader peptide -
DQM96_RS09455 1854189..1854440 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
DQM96_RS09460 1854437..1854691 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
DQM96_RS09465 1854774..1855598 + 825 WP_000754763.1 SDR family oxidoreductase -
DQM96_RS09470 1855644..1856574 + 931 Protein_1743 LysR family transcriptional regulator -
DQM96_RS09475 1856789..1856851 + 63 WP_010723108.1 membrane protein YoeI -
DQM96_RS09480 1856841..1858199 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
DQM96_RS09485 1858378..1859436 + 1059 WP_000492305.1 transport protein YeeE -
DQM96_RS09490 1859450..1859677 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T292161 WP_000767829.1 NZ_LS483296:1854437-1854691 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT292161 WP_001259255.1 NZ_LS483296:1854189-1854440 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References