Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2783868..2784523 Replicon chromosome
Accession NZ_LS398590
Organism Bordetella pertussis strain VS393 isolate Bordetella pertussis

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag EAO55_RS13480 Protein ID WP_047122780.1
Coordinates 2784272..2784523 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag EAO55_RS13475 Protein ID WP_003809516.1
Coordinates 2783868..2784269 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAO55_RS13445 2779051..2780073 - 1023 WP_003809532.1 amino acid ABC transporter substrate-binding protein -
EAO55_RS13450 2780210..2781247 - 1038 WP_023853543.1 threonylcarbamoyl-AMP synthase -
EAO55_RS13455 2781267..2782457 - 1191 WP_010930406.1 5-(carboxyamino)imidazole ribonucleotide synthase -
EAO55_RS13460 2782460..2782975 - 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
EAO55_RS13465 2783125..2783604 - 480 WP_010930405.1 disulfide bond formation protein B -
EAO55_RS13470 2783612..2783848 - 237 WP_010930404.1 membrane protein -
EAO55_RS13475 2783868..2784269 - 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
EAO55_RS13480 2784272..2784523 - 252 WP_047122780.1 type II toxin-antitoxin system MqsR family toxin Toxin
EAO55_RS13485 2784578..2785459 - 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
EAO55_RS13490 2785684..2786130 + 447 WP_003819827.1 GFA family protein -
EAO55_RS13495 2786215..2787279 - 1065 WP_003809510.1 fructose-bisphosphate aldolase class II -
EAO55_RS13500 2787416..2787997 - 582 WP_019247931.1 molybdenum cofactor biosysynthesis protein -
EAO55_RS13505 2788232..2789362 + 1131 WP_010930401.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(10-82)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 8952.52 Da        Isoelectric Point: 9.7242

>T292111 WP_047122780.1 NZ_LS398590:c2784523-2784272 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Download         Length: 252 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT292111 WP_003809516.1 NZ_LS398590:c2784269-2783868 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References