Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1075493..1076147 Replicon chromosome
Accession NZ_LR890714
Organism Escherichia coli isolate MSB1_6C-sc-2280315

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag JMW19_RS05185 Protein ID WP_000244781.1
Coordinates 1075740..1076147 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag JMW19_RS05180 Protein ID WP_001564007.1
Coordinates 1075493..1075759 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW19_RS05160 1071581..1073014 - 1434 WP_001564009.1 6-phospho-beta-glucosidase BglA -
JMW19_RS05165 1073059..1073370 + 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
JMW19_RS05170 1073534..1074193 + 660 WP_000250274.1 hemolysin III family protein -
JMW19_RS05175 1074270..1075250 - 981 WP_001564008.1 tRNA-modifying protein YgfZ -
JMW19_RS05180 1075493..1075759 + 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
JMW19_RS05185 1075740..1076147 + 408 WP_000244781.1 protein YgfX Toxin
JMW19_RS05190 1076187..1076708 - 522 WP_001055874.1 flavodoxin FldB -
JMW19_RS05195 1076820..1077716 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JMW19_RS05200 1077741..1078451 + 711 WP_001564005.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMW19_RS05205 1078457..1080190 + 1734 WP_001564004.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T291925 WP_000244781.1 NZ_LR890714:1075740-1076147 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT291925 WP_001564007.1 NZ_LR890714:1075493-1075759 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References