Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 156627..157264 Replicon chromosome
Accession NZ_LR890523
Organism Burkholderia cepacia isolate MINF_4A-sc-2280433

Toxin (Protein)


Gene name vapC Uniprot ID A0A364GQ02
Locus tag ISX57_RS00725 Protein ID WP_034201143.1
Coordinates 156863..157264 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A364GPY9
Locus tag ISX57_RS00720 Protein ID WP_034201144.1
Coordinates 156627..156863 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISX57_RS00700 152003..153019 + 1017 WP_077190295.1 helix-turn-helix domain-containing protein -
ISX57_RS00705 153114..154211 - 1098 WP_194131029.1 ADP-heptose--LPS heptosyltransferase -
ISX57_RS00710 154208..155911 - 1704 WP_034201145.1 thiamine pyrophosphate-binding protein -
ISX57_RS00715 156226..156509 + 284 Protein_138 type II toxin-antitoxin system RelE/ParE family toxin -
ISX57_RS00720 156627..156863 + 237 WP_034201144.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ISX57_RS00725 156863..157264 + 402 WP_034201143.1 type II toxin-antitoxin system VapC family toxin Toxin
ISX57_RS00730 157332..158720 - 1389 WP_194131030.1 L-serine ammonia-lyase -
ISX57_RS00735 158751..159893 - 1143 WP_006496280.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15099.33 Da        Isoelectric Point: 6.2271

>T291272 WP_034201143.1 NZ_LR890523:156863-157264 [Burkholderia cepacia]
MPRFMLDTNMCIYLMKNQPEQVARRFARCYTGDVVMSAITYAELEYGLTACVNPARERRHLAALIEDIPVAPFDAAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLND

Download         Length: 402 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8982.15 Da        Isoelectric Point: 6.4701

>AT291272 WP_034201144.1 NZ_LR890523:156627-156863 [Burkholderia cepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTQVLAKFAKFGPDFMADGRGDHEQAEREGL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364GQ02

Antitoxin

Source ID Structure
AlphaFold DB A0A364GPY9

References