Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 54962..55605 Replicon plasmid 2
Accession NZ_LR890501
Organism Klebsiella pneumoniae isolate KSB1_5H-sc-2280283

Toxin (Protein)


Gene name vagD Uniprot ID A0A3A3ZBE4
Locus tag JMX76_RS27335 Protein ID WP_007374381.1
Coordinates 54962..55378 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID G8LQB1
Locus tag JMX76_RS27340 Protein ID WP_007853351.1
Coordinates 55375..55605 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX76_RS27310 50446..50784 - 339 WP_007374386.1 carboxymuconolactone decarboxylase family protein -
JMX76_RS27315 50801..51370 - 570 WP_042936984.1 TetR/AcrR family transcriptional regulator -
JMX76_RS27320 51554..52111 - 558 WP_007374384.1 OsmC family protein -
JMX76_RS27325 52320..53342 - 1023 WP_007374383.1 hypothetical protein -
JMX76_RS27330 53327..54889 - 1563 WP_042936981.1 AAA family ATPase -
JMX76_RS27335 54962..55378 - 417 WP_007374381.1 type II toxin-antitoxin system VapC family toxin Toxin
JMX76_RS27340 55375..55605 - 231 WP_007853351.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JMX76_RS27345 56423..57658 - 1236 WP_023288250.1 RhtX/FptX family siderophore transporter -
JMX76_RS27350 57671..59122 - 1452 WP_075917562.1 PepSY domain-containing protein -
JMX76_RS27355 59080..59328 - 249 WP_023288248.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..161308 161308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15105.57 Da        Isoelectric Point: 7.8882

>T291211 WP_007374381.1 NZ_LR890501:c55378-54962 [Klebsiella pneumoniae]
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYAEMRFGATGPKAAPRHVQLVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8674.77 Da        Isoelectric Point: 4.4692

>AT291211 WP_007853351.1 NZ_LR890501:c55605-55375 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A3ZBE4

Antitoxin

Source ID Structure
AlphaFold DB A0A3A3Z894

References