Detailed information of TA system TA291149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4856954..4858635
• Replicon: chromosome
• Accession: NZ_LR890474
• Organism: Klebsiella pneumoniae isolate INF358-sc-2280191

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: JMX23_RS23620
• Protein ID: WP_117062769.1
• Coordinates: 4856954..4857871 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: JMX23_RS23625
• Protein ID: WP_004177809.1
• Coordinates: 4857877..4858635 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMX23_RS23600	4852260..4853780	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
JMX23_RS23605	4853777..4854775	+	999	WP_002885172.1	ribose ABC transporter permease	-
JMX23_RS23610	4854806..4855747	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
JMX23_RS23615	4855822..4856829	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
JMX23_RS23620	4856954..4857871	-	918	WP_117062769.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JMX23_RS23625	4857877..4858635	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JMX23_RS23630	4858721..4859449	-	729	WP_002885152.1	response regulator transcription factor	-
JMX23_RS23635	4859722..4861869	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
JMX23_RS23640	4862215..4862901	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34632.03 Da
• Isoelectric Point: 5.2461

>T291149 WP_117062769.1 NZ_LR890474:c4857871-4856954 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLETVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT291149 WP_004177809.1 NZ_LR890474:c4858635-4857877 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A6TH05