Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4698130..4698646 Replicon chromosome
Accession NZ_LR890474
Organism Klebsiella pneumoniae isolate INF358-sc-2280191

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag JMX23_RS22810 Protein ID WP_009309309.1
Coordinates 4698130..4698414 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMX23_RS22815 Protein ID WP_002886901.1
Coordinates 4698404..4698646 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX23_RS22785 4693525..4693833 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
JMX23_RS22790 4693918..4694064 + 147 WP_165455169.1 hypothetical protein -
JMX23_RS22795 4694094..4694837 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMX23_RS22800 4695194..4697332 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMX23_RS22805 4697662..4698126 + 465 WP_087759217.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMX23_RS22810 4698130..4698414 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX23_RS22815 4698404..4698646 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMX23_RS22820 4698724..4700634 - 1911 WP_117062776.1 BglG family transcription antiterminator -
JMX23_RS22825 4700657..4701811 - 1155 WP_040225313.1 lactonase family protein -
JMX23_RS22830 4701878..4702618 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T291148 WP_009309309.1 NZ_LR890474:c4698414-4698130 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT291148 WP_002886901.1 NZ_LR890474:c4698646-4698404 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References