Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2620783..2622371 Replicon chromosome
Accession NZ_LR890474
Organism Klebsiella pneumoniae isolate INF358-sc-2280191

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMX23_RS12840 Protein ID WP_087830461.1
Coordinates 2620783..2622105 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMX23_RS12845 Protein ID WP_002904790.1
Coordinates 2622105..2622371 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX23_RS12825 2615839..2618340 + 2502 WP_048299446.1 fimbrial biogenesis outer membrane usher protein -
JMX23_RS12830 2618328..2619332 + 1005 WP_004190163.1 type 1 fimbrial protein -
JMX23_RS12835 2619474..2620766 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX23_RS12840 2620783..2622105 - 1323 WP_087830461.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX23_RS12845 2622105..2622371 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX23_RS12850 2622636..2622962 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMX23_RS12855 2622959..2623459 - 501 WP_032412207.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX23_RS12860 2623437..2624816 - 1380 WP_048299445.1 purine permease -
JMX23_RS12865 2625162..2626316 + 1155 WP_020804972.1 FAD-dependent urate hydroxylase HpxO -
JMX23_RS12870 2626297..2627220 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49201.49 Da        Isoelectric Point: 7.5357

>T291145 WP_087830461.1 NZ_LR890474:c2622105-2620783 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT291145 WP_002904790.1 NZ_LR890474:c2622371-2622105 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References