Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 56027..56763 Replicon plasmid 2
Accession NZ_LR890472
Organism Klebsiella pneumoniae isolate INF168-sc-2280023

Toxin (Protein)


Gene name tacT Uniprot ID A0A8T5ZF70
Locus tag JMX14_RS26180 Protein ID WP_004187044.1
Coordinates 56281..56763 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMX14_RS26175 Protein ID WP_003026799.1
Coordinates 56027..56293 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX14_RS26160 51499..52893 + 1395 WP_032439652.1 cytosine permease -
JMX14_RS26165 52905..54113 + 1209 WP_032448288.1 imidazolonepropionase -
JMX14_RS26170 54106..54915 + 810 WP_023329017.1 N-formylglutamate deformylase -
JMX14_RS26175 56027..56293 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
JMX14_RS26180 56281..56763 + 483 WP_004187044.1 GNAT family N-acetyltransferase Toxin
JMX14_RS26185 56970..58316 + 1347 WP_077254728.1 ISNCY family transposase -
JMX14_RS26190 58365..58763 + 399 WP_032422684.1 helix-turn-helix domain-containing protein -
JMX14_RS26195 58911..59018 - 108 Protein_58 IS3 family transposase -
JMX14_RS26200 59016..59186 - 171 Protein_59 transposase -
JMX14_RS26205 59296..60232 + 937 Protein_60 ISNCY family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..177028 177028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17280.93 Da        Isoelectric Point: 8.7197

>T291137 WP_004187044.1 NZ_LR890472:56281-56763 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTYERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT291137 WP_003026799.1 NZ_LR890472:56027-56293 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References