Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4824523..4825039 Replicon chromosome
Accession NZ_LR890471
Organism Klebsiella pneumoniae isolate INF168-sc-2280023

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag JMX14_RS23275 Protein ID WP_004894697.1
Coordinates 4824523..4824807 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMX14_RS23280 Protein ID WP_002886901.1
Coordinates 4824797..4825039 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX14_RS23250 4819918..4820226 - 309 WP_004894688.1 PTS sugar transporter subunit IIB -
JMX14_RS23255 4820311..4820484 + 174 WP_002886906.1 hypothetical protein -
JMX14_RS23260 4820487..4821230 + 744 WP_004894691.1 MurR/RpiR family transcriptional regulator -
JMX14_RS23265 4821588..4823726 + 2139 WP_023325427.1 anaerobic ribonucleoside-triphosphate reductase -
JMX14_RS23270 4824055..4824519 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMX14_RS23275 4824523..4824807 - 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX14_RS23280 4824797..4825039 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMX14_RS23285 4825117..4827027 - 1911 WP_023325426.1 BglG family transcription antiterminator -
JMX14_RS23290 4827050..4828204 - 1155 WP_004178372.1 lactonase family protein -
JMX14_RS23295 4828271..4829011 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T291134 WP_004894697.1 NZ_LR890471:c4824807-4824523 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT291134 WP_002886901.1 NZ_LR890471:c4825039-4824797 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References