Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2855707..2857295 Replicon chromosome
Accession NZ_LR890471
Organism Klebsiella pneumoniae isolate INF168-sc-2280023

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag JMX14_RS13865 Protein ID WP_004892016.1
Coordinates 2855973..2857295 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMX14_RS13860 Protein ID WP_004176198.1
Coordinates 2855707..2855973 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX14_RS13835 2850858..2851781 + 924 WP_004892028.1 LysR family hpxDE operon transcriptional regulator HpxR -
JMX14_RS13840 2851762..2852916 - 1155 WP_004892025.1 FAD-dependent urate hydroxylase HpxO -
JMX14_RS13845 2853262..2854641 + 1380 WP_004176204.1 purine permease -
JMX14_RS13850 2854619..2855119 + 501 WP_004892023.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX14_RS13855 2855116..2855442 + 327 WP_004892019.1 hydroxyisourate hydrolase -
JMX14_RS13860 2855707..2855973 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX14_RS13865 2855973..2857295 + 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX14_RS13870 2857312..2858604 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX14_RS13875 2858746..2859750 - 1005 WP_004892012.1 type 1 fimbrial protein -
JMX14_RS13880 2859738..2862239 - 2502 WP_004892009.1 fimbrial biogenesis outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - iroE / mgtC 2820223..3048633 228410


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T291125 WP_004892016.1 NZ_LR890471:2855973-2857295 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT291125 WP_004176198.1 NZ_LR890471:2855707-2855973 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References