Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2641333..2642921 Replicon chromosome
Accession NZ_LR890374
Organism Klebsiella pneumoniae isolate INF250-sc-2280154

Toxin (Protein)


Gene name hipA Uniprot ID A6T928
Locus tag JMW58_RS13015 Protein ID WP_004176197.1
Coordinates 2641333..2642655 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMW58_RS13020 Protein ID WP_032417111.1
Coordinates 2642655..2642921 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW58_RS13000 2636389..2638890 + 2502 WP_016831617.1 fimbrial biogenesis outer membrane usher protein -
JMW58_RS13005 2638878..2639882 + 1005 WP_004176196.1 type 1 fimbrial protein -
JMW58_RS13010 2640024..2641316 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW58_RS13015 2641333..2642655 - 1323 WP_004176197.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW58_RS13020 2642655..2642921 - 267 WP_032417111.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW58_RS13025 2643186..2643512 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMW58_RS13030 2643509..2644009 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW58_RS13035 2643987..2645366 - 1380 WP_032429500.1 purine permease -
JMW58_RS13040 2645712..2646866 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMW58_RS13045 2646847..2647770 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2442564..2676588 234024


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49111.41 Da        Isoelectric Point: 7.5357

>T290810 WP_004176197.1 NZ_LR890374:c2642655-2641333 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9926.32 Da        Isoelectric Point: 8.5912

>AT290810 WP_032417111.1 NZ_LR890374:c2642921-2642655 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETASAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6T928

Antitoxin

Source ID Structure

References