Detailed information of TA system TA290780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 189206..189732
• Replicon: plasmid 2
• Accession: NZ_LR890361
• Organism: Klebsiella pneumoniae isolate INF049-sc-2279950

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1EXL1
• Locus tag: JMW75_RS26490
• Protein ID: WP_000323025.1
• Coordinates: 189206..189493 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: J5W3H0
• Locus tag: JMW75_RS26495
• Protein ID: WP_004196370.1
• Coordinates: 189493..189732 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW75_RS26450	184537..184761	-	225	WP_014343499.1	hypothetical protein	-
JMW75_RS26455	184772..184984	-	213	WP_019706020.1	hypothetical protein	-
JMW75_RS26460	185045..185401	-	357	WP_019706019.1	hypothetical protein	-
JMW75_RS26465	186242..186559	-	318	WP_015065519.1	hypothetical protein	-
JMW75_RS26470	186574..186924	-	351	WP_049245656.1	hypothetical protein	-
JMW75_RS26475	186921..187193	-	273	WP_032425552.1	hypothetical protein	-
JMW75_RS26480	187891..188049	-	159	WP_014343509.1	type I toxin-antitoxin system Hok family toxin	-
JMW75_RS26485	188121..189317	+	1197	WP_064185306.1	IS481 family transposase	-
JMW75_RS26490	189206..189493	-	288	WP_000323025.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
JMW75_RS26495	189493..189732	-	240	WP_004196370.1	type II toxin-antitoxin system antitoxin RelB	Antitoxin
JMW75_RS26500	189983..190348	+	366	WP_009651956.1	hypothetical protein	-
JMW75_RS26505	190392..191129	+	738	WP_008460272.1	HupE/UreJ family protein	-
JMW75_RS26510	191143..191832	+	690	WP_004196322.1	hypothetical protein	-
JMW75_RS26515	191863..193239	-	1377	Protein_200	chromate efflux transporter	-
JMW75_RS26520	193196..194173	-	978	WP_004196334.1	chromate resistance protein	-
JMW75_RS26525	194203..194395	+	193	Protein_202	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	mrkA / mrkB / mrkC / mrkD / mrkF / mrkJ	1..233670	233670

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-79)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11225.22 Da
• Isoelectric Point: 10.1967

>T290780 WP_000323025.1 NZ_LR890361:c189493-189206 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Nucleotide

• Length: 288 bp

>T290780 NZ_LR890361:c189493-189206 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9018.43 Da
• Isoelectric Point: 4.3894

>AT290780 WP_004196370.1 NZ_LR890361:c189732-189493 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Nucleotide

• Length: 240 bp

>AT290780 NZ_LR890361:c189732-189493 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• PDB: 4V7K
• PDB: 4V7J
• PDB: 4FXI
• PDB: 4FXE
• PDB: 2KC8
• PDB: 4FXH
• PDB: 2KC9

Antitoxin

• AlphaFold DB: A0A2J4QRH4