Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4634667..4635183 Replicon chromosome
Accession NZ_LR890360
Organism Klebsiella pneumoniae isolate INF049-sc-2279950

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JMW75_RS22665 Protein ID WP_002886902.1
Coordinates 4634667..4634951 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMW75_RS22670 Protein ID WP_002886901.1
Coordinates 4634941..4635183 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW75_RS22640 4630083..4630391 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
JMW75_RS22645 4630476..4630649 + 174 WP_032410138.1 hypothetical protein -
JMW75_RS22650 4630652..4631395 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
JMW75_RS22655 4631752..4633890 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMW75_RS22660 4634199..4634663 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMW75_RS22665 4634667..4634951 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW75_RS22670 4634941..4635183 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMW75_RS22675 4635261..4637171 - 1911 WP_009486549.1 BglG family transcription antiterminator -
JMW75_RS22680 4637194..4638348 - 1155 WP_023302389.1 lactonase family protein -
JMW75_RS22685 4638415..4639155 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T290773 WP_002886902.1 NZ_LR890360:c4634951-4634667 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT290773 WP_002886901.1 NZ_LR890360:c4635183-4634941 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References