Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2549259..2550847 Replicon chromosome
Accession NZ_LR890360
Organism Klebsiella pneumoniae isolate INF049-sc-2279950

Toxin (Protein)


Gene name hipA Uniprot ID A0A485W5A2
Locus tag JMW75_RS12465 Protein ID WP_023342812.1
Coordinates 2549259..2550581 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMW75_RS12470 Protein ID WP_024622638.1
Coordinates 2550581..2550847 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW75_RS12450 2544315..2546816 + 2502 WP_023342811.1 fimbrial biogenesis outer membrane usher protein -
JMW75_RS12455 2546804..2547808 + 1005 WP_004224758.1 type 1 fimbrial protein -
JMW75_RS12460 2547950..2549242 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW75_RS12465 2549259..2550581 - 1323 WP_023342812.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW75_RS12470 2550581..2550847 - 267 WP_024622638.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW75_RS12475 2551112..2551438 - 327 WP_004184023.1 hydroxyisourate hydrolase -
JMW75_RS12480 2551435..2551935 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW75_RS12485 2551913..2553292 - 1380 WP_004184021.1 purine permease -
JMW75_RS12490 2553638..2554792 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMW75_RS12495 2554773..2555696 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2351648..2584505 232857


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5358

>T290769 WP_023342812.1 NZ_LR890360:c2550581-2549259 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEVNAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9924.30 Da        Isoelectric Point: 8.5912

>AT290769 WP_024622638.1 NZ_LR890360:c2550847-2550581 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYMKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A485W5A2

Antitoxin

Source ID Structure

References