Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 358975..359621 Replicon chromosome
Accession NZ_LR890360
Organism Klebsiella pneumoniae isolate INF049-sc-2279950

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag JMW75_RS01660 Protein ID WP_016529833.1
Coordinates 358975..359322 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag JMW75_RS01665 Protein ID WP_002920557.1
Coordinates 359322..359621 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW75_RS01650 354901..356334 + 1434 WP_002920564.1 glycogen synthase GlgA -
JMW75_RS01655 356352..358799 + 2448 WP_002920561.1 glycogen phosphorylase -
JMW75_RS01660 358975..359322 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW75_RS01665 359322..359621 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
JMW75_RS01670 359684..361192 - 1509 WP_023301456.1 glycerol-3-phosphate dehydrogenase -
JMW75_RS01675 361397..361726 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
JMW75_RS01680 361777..362607 + 831 WP_024622927.1 rhomboid family intramembrane serine protease GlpG -
JMW75_RS01685 362657..363415 + 759 WP_032456686.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T290763 WP_016529833.1 NZ_LR890360:358975-359322 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT290763 WP_002920557.1 NZ_LR890360:359322-359621 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References