Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 80118..80792 Replicon plasmid 2
Accession NZ_LR890357
Organism Klebsiella pneumoniae isolate INF231-sc-2280121

Toxin (Protein)


Gene name higB Uniprot ID A0A5Q9LMS5
Locus tag JMV88_RS26605 Protein ID WP_032720638.1
Coordinates 80118..80441 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMV88_RS26610 Protein ID WP_032720637.1
Coordinates 80490..80792 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV88_RS26580 75300..77012 + 1713 WP_038992633.1 ROK family protein -
JMV88_RS26585 77442..77924 - 483 WP_032720647.1 GNAT family N-acetyltransferase -
JMV88_RS26590 77912..78178 - 267 WP_003026799.1 DUF1778 domain-containing protein -
JMV88_RS26595 78459..79061 + 603 Protein_76 transposase -
JMV88_RS26600 79388..79940 + 553 Protein_77 DUF4113 domain-containing protein -
JMV88_RS26605 80118..80441 + 324 WP_032720638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV88_RS26610 80490..80792 + 303 WP_032720637.1 helix-turn-helix domain-containing protein Antitoxin
JMV88_RS26615 80835..81002 - 168 WP_153591440.1 hypothetical protein -
JMV88_RS26620 81190..81369 - 180 WP_032720701.1 hypothetical protein -
JMV88_RS26625 81393..81776 - 384 WP_032720636.1 hypothetical protein -
JMV88_RS26630 81881..82453 - 573 WP_032720635.1 GNAT family N-acetyltransferase -
JMV88_RS26635 82455..83243 - 789 WP_032720700.1 TSUP family transporter -
JMV88_RS26640 83279..84199 - 921 WP_050548604.1 TauD/TfdA family dioxygenase -
JMV88_RS26645 84502..84996 - 495 WP_064167959.1 hypothetical protein -
JMV88_RS26650 85027..85599 - 573 WP_044266753.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..195539 195539
- flank IS/Tn - - 78672..79061 389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-83)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12372.29 Da        Isoelectric Point: 9.6240

>T290760 WP_032720638.1 NZ_LR890357:80118-80441 [Klebsiella pneumoniae]
MNYLEFVETSAFSGLRKELMDDDEFRELQTYLLEAHDRGDTISHTGGCRKIRWGRPGMGKRGGVRVIYYVRLASGRLYLL
LIYPKNAKDELSEKEKAVMKALTQQLK

Download         Length: 324 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11211.12 Da        Isoelectric Point: 7.3611

>AT290760 WP_032720637.1 NZ_LR890357:80490-80792 [Klebsiella pneumoniae]
MEKKLFDALISSMEEMVAIENGQIQPAAEQVHRHTLPDVKAIRKHAGMKQAEFAEVVGASVDLVRSWEQQRRVPSGIALK
MLCLIEREPALINTLRGIHV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LMS5

Antitoxin

Source ID Structure

References