Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4881791..4882307 Replicon chromosome
Accession NZ_LR890356
Organism Klebsiella pneumoniae isolate INF231-sc-2280121

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag JMV88_RS23585 Protein ID WP_004894697.1
Coordinates 4881791..4882075 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMV88_RS23590 Protein ID WP_002886901.1
Coordinates 4882065..4882307 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV88_RS23560 4877186..4877494 - 309 WP_004894688.1 PTS sugar transporter subunit IIB -
JMV88_RS23565 4877579..4877752 + 174 WP_002886906.1 hypothetical protein -
JMV88_RS23570 4877755..4878498 + 744 WP_004894691.1 MurR/RpiR family transcriptional regulator -
JMV88_RS23575 4878856..4880994 + 2139 WP_023325427.1 anaerobic ribonucleoside-triphosphate reductase -
JMV88_RS23580 4881323..4881787 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMV88_RS23585 4881791..4882075 - 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV88_RS23590 4882065..4882307 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMV88_RS23595 4882385..4884295 - 1911 WP_023325426.1 BglG family transcription antiterminator -
JMV88_RS23600 4884318..4885472 - 1155 WP_004178372.1 lactonase family protein -
JMV88_RS23605 4885539..4886279 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T290757 WP_004894697.1 NZ_LR890356:c4882075-4881791 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT290757 WP_002886901.1 NZ_LR890356:c4882307-4882065 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References