Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4027811..4028408 Replicon chromosome
Accession NZ_LR890356
Organism Klebsiella pneumoniae isolate INF231-sc-2280121

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag JMV88_RS19590 Protein ID WP_004893639.1
Coordinates 4028091..4028408 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag JMV88_RS19585 Protein ID WP_004142561.1
Coordinates 4027811..4028098 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV88_RS19555 4023891..4024139 + 249 WP_002893037.1 DUF1158 domain-containing protein -
JMV88_RS19560 4024157..4024498 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
JMV88_RS19565 4024529..4025644 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
JMV88_RS19570 4025824..4026405 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
JMV88_RS19575 4026405..4026773 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
JMV88_RS19580 4026893..4027546 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
JMV88_RS19585 4027811..4028098 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
JMV88_RS19590 4028091..4028408 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV88_RS19595 4028593..4029636 - 1044 WP_004893645.1 DUF2157 domain-containing protein -
JMV88_RS19600 4030302..4031168 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
JMV88_RS19605 4031277..4032704 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T290754 WP_004893639.1 NZ_LR890356:c4028408-4028091 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT290754 WP_004142561.1 NZ_LR890356:c4028098-4027811 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References